Cyclodextrins

Electrospun Fibers of Cyclodextrins and Poly(cyclodextrins).

Cyclodextrins (CDs) can endow electrospun fibers with outstanding performance characteristics that rely on their ability to form inclusion complexes. The inclusion complexes can be blended with electrospinnable polymers or used themselves as main components of electrospun nanofibers. In general, the presence of CDs promotes drug release in aqueous media, but they may also play other roles such ...

Nanostructuring polymers with cyclodextrins

Cristian C. Rusa, Min Wei, Todd A. Bullions, Xintao Shuai, Tamer Uyar and Alan E. Tonelli* Fiber & Polymer Science Program, North Carolina State University, Campus Box 8301, Raleigh, NC 27695-8301, USA Center For High Performance Manufacturing, ESM, Mail Code: 0219, 219 Norris Hall, Virginia Tech, Blacksburg, VA 24061-0219, USA Department of Biomedical Engineering, Case Western Reserve Universi...

Cyclodextrins used as excipients

Melarsoprol-cyclodextrins inclusion complexes.

Melarsoprol, a water-insoluble drug, is mainly used in the treatment of trypanosomiasis and has demonstrated an in vitro activity on myeloid and lymphoid leukemia derived cell lines. It is marketed as a very poorly tolerated non-aqueous solution (Arsobal). The aim of our work was to develop melarsoprol-cyclodextrin complexes in order to improve the tolerability and the bioavailability of melars...

Cyclodextrins as pharmaceutical solubilizers.

Cyclodextrins are useful functional excipients that have enjoyed widespread attention and use. The basis for this popularity from a pharmaceutical standpoint, is the ability of these materials to interact with poorly water-soluble drugs and drug candidates resulting in an increase in their apparent water solubility. The mechanism for this solubilization is rooted in the ability of cyclodextrin ...